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Big Mike
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Date Joined Dec 2000
Total Posts : 182
 
   Posted 4/2/2001 4:24 PM (GMT -4)    Quote This PostAlert An Admin About This Post.
LEF sells a product called Ibuprofen Dolgel Gel. Natures Plus sells a glucosamine/chondroitin/msm cream. The claim is that the healing ingredients in these products seep through the skin and act directly on the affected sore area. Im skeptical. It sounds almost too good to be true. Can healing ingredients actually get through the skin as claimed?

::Well there certainly are things that can get through the skin and into the system, for example testosterone patches and gel, progesterone creams, etc. Here are two trials which showed that topical ibuprofen is effective.

Eur J Clin Pharmacol 2000 Sep;56(6-7):459-62
Assay of topically administered ibuprofen using a model of post-injury hypersensitivity. A randomised, double-blind, placebo-controlled study.
McCormack K, Kidd BL, Morris V
Drug Research Group, McCormack Limited, Leighton Buzzard, UK.

OBJECTIVE: To develop a reliable assay for quantifying the analgesic efficacy of non-steroidal anti-inflammatory drugs (NSAIDs) using a model that is accepted as a paradigm of clinical pain. SUBJECTS: Fifteen normal subjects, all of whom were volunteers from medical school staff, took part in the study.
METHODS: Capsaicin (20 microl) in solution (0.03 mg/ml) was applied to the volar surface of the forearm, and the skin was maintained at a constant temperature using a thermal stimulator. The magnitude of the surrounding area of mechanical allodynia to a brush stimulus (i.e. a clinical correlate of tenderness to touch) was assessed. Under double-blind, placebo-controlled conditions, the test was repeated using skin previously treated with ibuprofen gel or placebo.
RESULTS: A close linear relationship was observed between skin temperature over a range of 30 degrees C to 40 degrees C and the area of capsaicin-induced allodynia. Ibuprofen gel significantly reduced (P < 0.004) the area of touch-evoked allodynia at a constant skin temperature of 40 degrees C.
CONCLUSIONS: The thermal-facilitated adaptation of the capsaicin model described in this study represents an inexpensive and reliable assay for the effects of topical formulations of NSAID upon mechanical sensitivity. As such, it is a potential alternative to many clinical studies in which inherent confounding and bias can preclude a meaningful conclusion.
Publication Types:
Clinical trial
Randomized controlled trial
PMID: 11049007

Eur J Pain 2000;4(2):195-209
Plasma levels after peroral and topical ibuprofen and effects upon low pH-induced cutaneous and muscle pain.
Steen AE, Reeh PW, Geisslinger G, Steen KH
Klinik und Poliklinik fur Dermatologie der Universitat Bonn, Klinische Dermatophysiologie, Sigmund-Freud-Str. 25, Bonn, D-53105, Germany.

Cutaneous applications are gaining popularity in the treatment of cutaneous pain and of painful disorders in joints and muscle. The low pH-pain model in human skin has previously been able to demonstrate the effects of NSAIDs in dose-dependent manner and to establish time-effect relationships. We examined the analgesic action of ibuprofen after cutaneous application and compared the effects with oral administration. The two studies (with n = 12 subjects each) were performed in a double-blind, randomized fashion with a 1-week cross-over interval. In study 1 volunteers received intradermal infusions with phosphate buffered saline solution of pH 5.2 and received either 800 mg ibuprofen per os and topical placebo, or 4 g of a 5% commercial ibuprofen gel topically applied and oral placebo capsules, respectively. In study 2 the same protocol was applied with painful intramuscular infusion of stronger, isotonic phosphate buffer (pH 5.2). The flow rate of the pH-infusion was individually adjusted to induce pain with a magnitude of 20% on a visual analogue scale (ranging from no (0%) to unbearable pain (100%)). Ibuprofen (S-, R-) plasma levels after oral administrations were measured with HPLC, and after topical applications, by gas chromatography combined with mass spectroscopy to determine plasma levels in the range of ng/ml. In the cutaneous model pain ratings decreased to zero after topical verum gel within 45 min of the observation period of 55 min. Pain reduction after peroral ibuprofen was of the same magnitude, but was achieved within only 30 min. In the muscle model, the commercial ibuprofen gel did not reduce the pain in the acidic muscle. The peroral ibuprofen was less effective in the muscle compared to the skin pain model, although there was a significant progressive pain reduction within 55 min. Reasons for the differential susceptibility of cutaneous vs muscular acidosis pain to ibuprofen remain to be established. Copyright 2000 European Federation of Chapters of the International
Association for the Study of Pain.
Publication Types:
Clinical trial
Randomized controlled trial
PMID: 10957700

I could not find anything on PubMed specifically relating to any topically applied mixture of glucosamine/chondroitin/msm. While MSM might be able to carry glucosamine through the skin, chondroitin is a much larger molecule and I doubt that it would.::


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LefMirage
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   Posted 4/30/2001 2:53 PM (GMT -4)    Quote This PostAlert An Admin About This Post.
I have used the Ibuprofen gel from LEF with great success with my neck pain. And have had no problems with it so far. It has no real odor or smell and dries readily.
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