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Conquer
Registered Member

Date Joined Jul 2005
Total Posts : 10

Posted 10/7/2006 9:58 PM (GMT -5)

It would seem there is hope for the issue with this patent:

http://www.wipo.int/pctdb/en/wo.jsp?IA=US2004027547&DISPLAY=DESC

Cany somebody with knowledge of the patenting process comment on how far this might be from being a commmercial reality?

Note that the 'Documents' page appears to contain current correspondence relating to the status of the patent.

zorba990
Registered Member

Date Joined Jul 2004
Total Posts : 710

Posted 10/8/2006 5:26 PM (GMT -5)

Conquer said...

It would seem there is hope for the issue with this patent:

http://www.wipo.int/pctdb/en/wo.jsp?IA=US2004027547&DISPLAY=DESC

Cany somebody with knowledge of the patenting process comment on how far this might be from being a commmercial reality?

Note that the 'Documents' page appears to contain current correspondence relating to the status of the patent.

Its another cyclic AMP stimulator. Check out Forskolin.

Conquer
Registered Member

Date Joined Jul 2005
Total Posts : 10

Posted 10/9/2006 12:42 PM (GMT -5)

Can you explain a little more of what you know of this Zorba990?
Do you think there is reason to be hopeful about this one?

zorba990
Registered Member

Date Joined Jul 2004
Total Posts : 710

Posted 10/10/2006 3:11 PM (GMT -5)

Conquer said...
Can you explain a little more of what you know of this Zorba990?
Do you think there is reason to be hopeful about this one?

Not very much. I think cAMP is fascinating and forskolin / Coleus is very interesting in the way it manifests its effects (cAMP activation). cAMP probably has a role in hair growth as well as melanocyte signaling.

I'll probably be reformulating my topical to add the proper type of this along with some other new things.

Zach
Registered Member

Date Joined Oct 2006
Total Posts : 4

Posted 10/17/2006 5:38 PM (GMT -5)

How do you all think the glyconutrients from some of these glyconutrient suppliers compare?

GlycoWellness Int's Glyconutrients and this glyconutrients supplier Has anyone used either of these brands of glyconutrients before?

Thanks.

Clark

AussieDavid
Registered Member

Date Joined Mar 2006
Total Posts : 181

Posted 10/17/2006 5:42 PM (GMT -5)

On recommendation from my doctor, I included R-Dihydro-Lipoic Acid in my latest order with LEF. I then stumbled across another thread in this forum discussing Alpha Lipoic Acid. The discussion included comments that it caused rapid greying of hair.

http://forum.lef.org/default.aspx?f=35&m=17079

Can anyone give me advice in relation to whether or not I should take it if I am trying to reverse grey hair? My doctor recommended it to me for it's antioxidant qualities. I did not think to ask him at the time about its' effect on hair colour.

Also, I recently visited a trichologist in my continuing attempt to try and work out why I have almost totally grey hair, yet my brothers have virtually no grey at all (I'm 36, they are 38 and 34y/o). The trichologist took a hair sample and sent it to 'Doctors Data' Laboratory in Illinois. I'll scan the results and post them here when I get some more time, but my zinc/copper ratio was 2.27. A normal expected range is 4 - 20. The trichologist told me to stop zinc supplementation. Up until a couple of months before this test, I had been taking a bio-zinc tablet each day for approximatley 2-3 years. In that time the greying acclerated considerably, though I was definitely well on the path before I started the zinc supplementation. If my Zn/Cu ratio is LOWER than the normal range (as it is here), doesn't that mean I have low zinc levels in relation to copper levels? If so, I don't understand why the trichologist told me to stop zinc supplementation.

flowergirl
Registered Member

Date Joined May 2006
Total Posts : 54

Posted 10/22/2006 7:04 PM (GMT -5)

Doesn't cAMP work in the same way as bimatoprost, which will eventually wear out the melanocytes?

zorba990
Registered Member

Date Joined Jul 2004
Total Posts : 710

Posted 10/23/2006 10:14 AM (GMT -5)

flowergirl said...
Doesn't cAMP work in the same way as bimatoprost, which will eventually wear out the melanocytes?

Perhaps, and antioxidants particulary PABA may help keep this safer long term.

One thing that is interesting to me is the fact that although virtually everyone's hair goes gray at some point , not everyone develops loss of skin pigmentation ability. IOW the melanocytes in the skin continue to function and presumably be replaced even in dark skinned individuals whose hair has gone gray. Those melanocytes get activated by oxidative stimulation.

And even to the point where you may have gray beard hair but no problem tanning

in the skin underneath.

I am VERY curious at this point to know the blood vitamin D levels of people with gray hair, particularly those that have gone gray early.

flowergirl
Registered Member

Date Joined May 2006
Total Posts : 54

Posted 10/23/2006 8:38 PM (GMT -5)

why d vitamins? becos they are related to tanning? and if you were gonna add cAMP to your formula, how would you apply it? and doesnt that mean that the bimatoprost is worth using if it does the same job?

zorba990
Registered Member

Date Joined Jul 2004
Total Posts : 710

Posted 10/30/2006 11:28 AM (GMT -5)

flowergirl said...
why d vitamins? becos they are related to tanning? and if you were gonna add cAMP to your formula, how would you apply it? and doesnt that mean that the bimatoprost is worth using if it does the same job?

Unfortunately, Coleus (source for Forskolin, a cAMP activator) seems to cause dermatitis,

so it's off my list for the moment. I'm not interested in bimatoprost since it is not AFAIK

a naturally occuring substance with a human nutritional need.

A good discussion of vitamin D is going on here:

http://melanotan.org/cgi-bin/yabb/YaBB.pl?board=generaldiscII;action=display;num=1161450490

Since optimal D blood levels may be necessary for tanning, I am speculating that they may also be necessary for hair pigmentation. In addition, we already know that D3, along with other phytonutrients, stimulates stem cell production

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16522169&query_hl=15&itool=pubmed_docsum

Someone should do a study to find out if locally increasing vit D levels results in the replenishment of hair shaft melanocytes.

Also interesting is that mice lacking a vitamin D receptor lose their hair:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16419036&query_hl=7&itool=pubmed_docsum

Cosmetic manufacturers probably won't get FDA approval to add vitamin D to their products because of potential toxicity issues (since they can't easily control the dose someone would use/get). But we can add it to our own topicals.

StarGazer
Registered Member

Date Joined Nov 2006
Total Posts : 118

Posted 11/4/2006 7:18 PM (GMT -5)

Given the SOD tests on mice, I am wondering if GliSodin www.glisodin.com might help.

It's a little expensive, but apparently, it can bypass the digestive tract. Word is SOD is not effective because it's broken down by the digestive tract. GliSODin is supposed to be a breakthrough in this area. It's $30 for 60 caps at Swanson Vitamins. Not that expensive but I already spend too much on vitamins.

Even better might be the SOD topical that was mentioned earlier in this thread. Anyone tried that yet?

SOD is backed by solid lab research, unlike most other wang chung b.s. therapies listed in this thread. But, not sure if SOD orals might help.

I think the best hope right now is the Allergen patent that was used for glaucoma (sp?) Anyone planning on trying that? Allergen apparently does not plan on any clinical trials for grey hair.

I tried He Shou Wu for about 2.5 years without any success. Some have reported success with it, but I haven't. I'm about 30% grey, but in the past year, the rate of progression has really picked up. At this rate, I'll be totally grey soon, so I want to halt it if I can.

I'm dropping zinc supplementation (except for the multi). Also, I dropping Minoxidil.com's (Dr. Lee's) products and going back to just 5% Minoxidil - this time with the foam. Dr. Lee adds an acidic ingredient to his minoxidil that doesn't agree with my hair. Doubtful that is adding to the grey, but I'm not taking any chances.

I've read every thread on the board here and want to thank those who reported non-success with certain products and experiments. It's saved me tons of time and anguish.

I might try GliSODin soon. I was going to try PABA, but won't now.

Dr. James Baral - a derm in NYC discovered that when he applied a combo of Retin-A and a hydroxy acid, it not only turned his grey hair back to it's original color, but also tanned his forehead where he made the small application.

Any guesses on what the hydroxy acid was? He never did develop a product from that, and it pizzes me off that he won't tell anyone what it was. Seems to me that would be very safe and easy to develop at home.

Conquer
Registered Member

Date Joined Jul 2005
Total Posts : 10

Posted 11/6/2006 10:02 AM (GMT -5)

"Dr. James Baral - a derm in NYC discovered that when he applied a combo of Retin-A and a hydroxy acid, it not only turned his grey hair back to it's original color, but also tanned his forehead where he made the small application"

The above mentioned unfortunately was found to be unsuccessful in treating grey hair.

You mention that Allegran is not planning clinical trials - but surely the patent is backed with findings?

sfrbm
Registered Member

Date Joined Mar 2006
Total Posts : 20

Posted 11/6/2006 10:03 AM (GMT -5)

Life Extension AlREADY uses GliSODin in their SODZyme with GliSODin Formula

See http://search.lef.org/cgi-src-bin/MsmGo.exe?URL=http://www.lef.org/newshop/items/item00801.html

StarGazer
Registered Member

Date Joined Nov 2006
Total Posts : 118

Posted 11/6/2006 7:58 PM (GMT -5)

conquer - it's kind of irrelevant now that Dr. Baral won't release any product, but where did you hear that his concoction doesn't work for grey hair? Longevity Mag. reported about 10 years ago that he said it turned his grey hair back to its original color in areas where he accidentally smeared it (near his forehead).

sfrbm - after my post, I found the GliSODin LEF product and ordered some.

As for Allergen, they don't list any grey hair trials on their clinical trials page. You can contact them if you like, but I don't believe they are planning any grey hair trials for their glaucoma product.

orbit71
Registered Member

Date Joined Nov 2006
Total Posts : 3

Posted 11/10/2006 12:16 PM (GMT -5)

what about COSMELYNK ?

http://www.lynk-biotech.com/products.htm

Gaizz
Registered Member

Date Joined Jan 2006
Total Posts : 46

Posted 11/10/2006 12:59 PM (GMT -5)

orbit71 said...
what about COSMELYNK ?

http://www.lynk-biotech.com/products.htm

It's a dye....

Goku
Registered Member

Date Joined Nov 2005
Total Posts : 7

Posted 11/14/2006 12:00 AM (GMT -5)

zorba990 said...

greyboy said...

US PATENT: 20050214821

This is a patent filed by Loreal paris about reversing grey hair by fixing the genetic problem that causes it. apparently by administering "polynucleotide fragments" in a form of lotion or shampoo you can reverse grey hair. This patent is only brand new but hopefully a shampoo isn't far away. Its reassuring that it is in the hands of a big international company that would have the ability to release it quickly to the market. let me know what you all think.

Sounds like pTpT Thymidine Dinucleotide which was used to tan the skins of pigs and was going to be developed into a sunless tanning cream.

http://66.102.7.104/search?q=cache:QvvHJYSTurMJ:www.shopbloomfield.com/ironwill/CurrentIssue/ptpt.html+pTpT+thymidine+dinucleotide&hl=en

pTpT are little DNA fragments that the body uses to repair damaged DNA. They are also a a pigmentation signal so it would be unclear if the effect was through DNA repair or through stimulation of pigmentation response.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9356500&dopt=Citation

It would be interesting if the effect was through DNA repair but less so if it is simply stimulating an already tired system. Topical tyrosinase and DOPA like compunds are, IMHO also likely to be simply stimulating a worn out system and would be of limited us long term (like taking a cup of coffee to stimulate adrenals instead of giving them fuel like pantothenic acid <oversimplified> )

Hi, I was wondering you mentioned PTPT and then went on to comment on topical tyrosinase and DOPA like compounds; do you mean to say topical tyrosinase and DOPA like compounds can stimulate tanning in skin?

This would very valuable to me who lives in a very sunny climate with very fair and sensitive skin that has already accrued lots of sun damage. Please let me know.

Seems like pTpT would be too risky a thing to try right in that regard from what I've read until human clinicals have elucidated more on that.

island808
Registered Member

Date Joined May 2006
Total Posts : 43

Posted 11/14/2006 1:57 PM (GMT -5)

I've been taking 500 mg daily of PABA for close to four months now and haven't noticed any discernable reversal in graying.
What about HGH? Not the analogs or percursers but the real deal expensive injectable stuff. Any reports of gray reversal there? (I can't afford the $ to go that route but am just curious.)

gotsomegray
Registered Member

Date Joined Mar 2006
Total Posts : 72

Posted 12/7/2006 10:36 AM (GMT -5)

Just an update on my trials. I have not been on Reminex/Melancor for a year. I've been using resthairation shampoo for about four months now along with trying a couple different scalp massagers. I'm also taking anti-oxidants as a supplement. My latest is about a week ago I've started applying amla oil to my scalp a few nights a week for a couple hours. I don't have any progress as of yet, but I'm still going to keep on for now. In about six months if I don't see any progress, I think I may try Arganine.

ssphere
Registered Member

Date Joined Dec 2006
Total Posts : 4

Posted 12/7/2006 4:12 PM (GMT -5)

Almost 50% of my hair are gray and 10% on my chest and bear. I'm very keen to find a solution which can stop or reverse my grey hair growth.

I tried Melancor NH for3 months but did not find any difference. Want to knowif anyone has tried Herb China
http://www.herbchina2000.com/therapies/LGH.shtml

SS1984
Registered Member

Date Joined Aug 2006
Total Posts : 16

Posted 12/8/2006 6:14 PM (GMT -5)

On that site they say that you can get premature grey hair from masturbating too much....Yeah right, and Santa Claus really exists....

I've been trying PABA 500 mg for 4 months now, with no results...Best solution for grey hair : dye it.

- The above hypothesis rests on zinc depletion. - Mod.

easybrit
Registered Member

Date Joined Dec 2006
Total Posts : 5

Posted 12/10/2006 5:24 PM (GMT -5)

I am interested to hear a couple of suggestions on this topic that refer us to the hair dye shelves at the supermarket.

I've been using these products for many years, hair dye on the head every two months, and facial hair dye once a week or every two weeks on a short trimmed beard but have stopped after reading and subsequently researching the ingredients of these products - which all sound horrifyingly dangerous. Thed idea of the skin - particularly under the beard - absorbing these toxins is the stuff nightmares are made of.

Am I perhaps over-reacting here - or is just better to accept the gray hair and get on with my life.

I wonder! Any thoughts?

gotsomegray
Registered Member

Date Joined Mar 2006
Total Posts : 72

Posted 12/21/2006 11:56 AM (GMT -5)

Well, I've got another link for everyone that "sounds promising". I know that probably gets really old when going through this thread, but I would love to hear some comments on this. I will probably try this in a couple months after I'm done with my current experiments that haven't shown any benefit yet.

http://www.ghr15products.com/testimonials.html

This is another HGH releaser type of product that contains several essential amino acids.

P.Minton, MD
Registered Member

Date Joined Dec 2006
Total Posts : 123

Posted 12/21/2006 9:06 PM (GMT -5)

There is a theory that anything that opens up the small arteries serving the hair follicles reverses greying. Some drs claim that their arterial cleansing IVs reverse grey hair in some people.

brm
Registered Member

Date Joined Dec 2006
Total Posts : 154

Posted 12/29/2006 2:40 PM (GMT -5)

Hello.

I am a newbie on this forum and I have "bad" news for us all. None of the treatments I have been using works:
-3 months on 1000 mg PABA then 1 month on 2000 mg: no effect.

-5 months now on Ho shou wu twice a day: no effect.

-2 months on black sesam once a day: no effect.

- 1 year and a half intermittently on 3 g arginine + 5 g ornithine daily: no effect.

-2 months on topical melatonin: no effect,

unless it has rather made things worse as some UK study implies it may.
-7 years on moderate to high doses of beta-carotene: no effect

I also take biotin, a little topical tyrosine, 2 mg copper, 17 mg Zinc, multivit, flax lignans, etc...

What is there left to try?

I might go in for melatonan [does anyone know if there can be any results with this, hairwise? (Their search engine returns very few results)], topical copper peptides (has anyone had any success?) and injectable HGH.

The last resort will be Grecian. I heard that they had replaced lead acetate with something else that made the product less toxic (but was it THAT toxic) but les effective as well (?)...

Any comments, suggestions, questions appreciated.

Thank you.

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