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Alessio
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Date Joined May 2007
Total Posts : 104
| Posted 10/10/2007 11:27 AM (GMT -5) |   | | | |
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reverse
Registered Member
Date Joined May 2006
Total Posts : 64
| Posted 10/10/2007 12:59 PM (GMT -5) | | | I think 5-10 years is the standard answer for these companies and scientists. I emailed Dr Des Tobin over a year ago and i got a 5-10 year answer...so why, at this point, wouldn't it be 4-9 years? i bet 5 years from now, it will still be, guess what, 5-10 years away. | | Back to Top | | |
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StarGazer
Registered Member
Date Joined Nov 2006
Total Posts : 118
| Posted 10/11/2007 9:52 AM (GMT -5) | | | xtian -
What is your agenda? I have to wonder since you've only posted here twice, and you come out with this outlandish claim that Melanotan causes blindness.
There is ABSOLUTELY no evidence that Melanotan causes blindness. There has not been 1 case of that. That claim is so irresponsible, it is ridiculous.
And if you're referring to someone's claim on another board that Melanotan causes eye damage, there is NO scientific evidence of that, either.
Now, who should people believe? The researchers who have tested this drug in formal testing environments, or someone who out of the blue irresponsibly posts that Melanotan causes blindness?
I am not advocating that people take Melanotan, given that it is not approved by the FDA yet. But, the drug is in Phase III trials across several countries in Europe, and it will be in Phase III trials in Australia very soon. Anyone with any intelligence would realize the drug would not have progressed this far if it was not shown to be safe up to this point.
The regulators in both Europe and Australia have not found any serious side effects with this drug to date. And anyone who says otherwise does not know the facts. Period.
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Alessio
Registered Member
Date Joined May 2007
Total Posts : 104
| Posted 10/11/2007 9:58 AM (GMT -5) | | Reverse u have a point. They all give us 5-10 years answer. In 1997 Des Tobin said 10 years or more and the cure will be commercially available. Other scientists I have asked they said that the cure will be on the market in some or several years- so 5-10 years again.
http://web.ncf.ca/aj624/greyhair.html | | Back to Top | | |
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Alessio
Registered Member
Date Joined May 2007
Total Posts : 104
| Posted 10/11/2007 9:59 AM (GMT -5) | | But if the cure won`t be available witin 10 years then I believe it is too late for us who started greying a few years ago, because melanocytes don`t survive so long in grey hair.
Am I right? | | Back to Top | | |
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xtian
Registered Member
Date Joined Oct 2007
Total Posts : 30
| Posted 10/11/2007 4:21 PM (GMT -5) | | Stargazer,
how many posts do you think a person should do, to be able to warn others of the potential harming of a hormone injection sold on internet without any legal approval????
Because, you should know this, nobody is going to have any effect by simply swallowing a pill. Melanotan must be taken by a self injection.... Simply this should make people less irresponsible...
And, do you really think, for the brightest of your very personal intelligence, that REALLY the "simple" fact of a researcher telling you that a drug has been tested is enough to make you swallow it with joy and without any suspect?
And what about FDA approval???? wasn't LIPOBAY approved? Isn't NIMESULIDE still on the market???? Did you ever read about VIOXX????? How many others should I mention? Did you ever read ANY drug sheet where the side effects are written??? WHO DO YOU THINK SHOULD PEOPLE BELIEVE???? To a world of researchers and drug companies addicted to make business of the people suffering
or to a reasonable suggestion that, maybe, injecting yourself with a hormone isn't really the safest thing to do for REVERSING GREY HAIR (we are not talking about curing a severe illness)????
Now, there are cases of people that, after taking Melanotan for a while are getting harmed by the product. And if this isn't still enough for your brilliant intelligence, read this http://philadelphia.injuryboard.com
Now my posts are 3, do you think they're enough, or do you prefer to hear of a member of this forum claiming he's been harmed by the drug?
p.s. I'm sorry that my english isn't good as yours, but this is not my mother language.
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StarGazer
Registered Member
Date Joined Nov 2006
Total Posts : 118
| Posted 10/12/2007 9:58 AM (GMT -5) | | |
This is my last post about Melanotan, because this is a forum for grey hair, not tanning.
The link you provided shows some attorney (see ambulance chancer) page about latest FDA warnings, etc. There is nothing there that I did not already know about. The FDA is trying to stop illegal sale of Melanotan in the U.S. That is nothing new to me - I knew about that last month. The FDA never condones illegal sales of a drug that they have not yet approved.
For your information, the FDA has never said Melanotan is dangerous. The FDA has tried to stop someone in Tennessee from marketing Melanotan because it has not been approved yet. I can't argue with the FDA's response on that.
The FDA is expected to give the green light to formal clinical testing of Melanotan in the United States within 6 months (it could be much sooner than that). Of course, they are allowing this because they want to see how many U.S. citizens will become blinded by the drug trial, right?
Now, show us the link that has proof that Melanotan causes blindness. There is no proof of that - not even 1 documented case worldwide.
I have been studying Melanotan and following its research since 1990. Your post about it causing blindness without any documented proof was irresponsible on a public forum. It was so ludicrous, it was probably not even worthy of a response from anyone. But, unfortunately, there are a few people who actually believe what they hear, regardless of the source.
If you want to try to persuade others to avoid using Melanotan before it is proven safe by the FDA, I have no problem with that. But, if you're going to go around spreading false rumors about drugs, that blows all your credibility.
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modesto
Registered Member
Date Joined Sep 2007
Total Posts : 10
| Posted 10/12/2007 10:09 AM (GMT -5) | | This Patent published just last year looks really interesting and very promising. It uses grape seed extract topically for reversing grey hair and the inventors seem to know what they are talking about and sound very confident.
http://www.freepatentsonline.com/20060147567.html
Here are some extracts:
-"The present invention relates to methods of increasing tyrosinase synthesis, expression, or activity in a cell comprising administering at least one grape seed extract to the cell."
-"In another embodiment, the invention provides a method that includes topically applying a composition of GSE and a cosmetically suitable vehicle to the scalp of a mammal or other location where gray hair is present, to increase tyrosinase gene expression or melanin synthesis and thereby decrease gray appearance."
I bought some Grape Seed Extract the other day so I am going to try this immediately (daily) and see if anything happens in about 3 months. I will keep using the topical Lac-Hydrin Retin-A 3 times a week. | | Back to Top | | |
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Alessio
Registered Member
Date Joined May 2007
Total Posts : 104
| Posted 10/12/2007 10:13 AM (GMT -5) | | | | |
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Alessio
Registered Member
Date Joined May 2007
Total Posts : 104
| Posted 10/12/2007 12:10 PM (GMT -5) | | Here are three question and three answers from one hair scientist:
1. I have recently read that grey hair in the beggining of greying process still
have melanocytes and then they eventually die and hair turns white. Is that
true?
ANSWER: YES
2. Some scientists claim that as long as a few melanocytes are there they could
reverse the whitening process by reactivating these cells (someday in the
future).
ANSWER: MAYBE
3. So could you please tell me if the hair follicle have no more melanocytes
(they all die off) the reversal would no longer be possible or it would
still be possible?
ANSWER: MOST LIKELY
What that most likely mean that it is still possible or not????????????? | | Back to Top | | |
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Alessio
Registered Member
Date Joined May 2007
Total Posts : 104
| Posted 10/13/2007 10:31 AM (GMT -5) | | If I understand the scientists from L`Oreal, P&G and others they have allready succesfully reversed grey hair that they have grown in lab, but one of the major probem is that how to penetrate so large moolecule 4 mm down to reach the melanocytes. So other approaches have to be developed based on small molecules that could easily penetrate the skin.
Because the scope of interventions available to the cosmetics industry is broadly limited to topical solutions; otherwise, therapies risk classification as drugs. | | Back to Top | | |
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xtian
Registered Member
Date Joined Oct 2007
Total Posts : 30
| Posted 10/14/2007 7:49 PM (GMT -5) | | Dear stargazer, so it comes out you're one of those that are behind the product... I could have bet that!
This explains more than any other argument.... PERIOD | | Back to Top | | |
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AussieDavid
Registered Member
Date Joined Mar 2006
Total Posts : 181
| Posted 10/15/2007 9:53 AM (GMT -5) | |
StinkyJoe said...
AussieDavid said...
I also use Nizoral 2% shampoo twice a week ... According to Dr. Jonathan Wright, even minimal contact with topical or oral Nizoral (Ketoconazole) will cause levels of DHEA hormone to drop in a big way. If I recall correctly, NIzoral will completely wipe out DHEA.
I have used the shampoo and liked it, but I stopped when I got the info about DHEA. If you must use the shampoo, maybe you can replace the DHEA with supplements.
It's a vicous circle......I'm using the Nizoral to help stop hair loss. I've supplemented with DHEA in the past and I believe that was responsible for accelerating my hair loss in the period I was taking it.....thus I ended up adding the Nizoral to my program. | | Back to Top | | |
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cdkona
Registered Member
Date Joined Feb 2007
Total Posts : 38
| Posted 10/15/2007 10:01 AM (GMT -5) | |
modesto said...This Patent published just last year looks really interesting and very promising. It uses grape seed extract topically for reversing grey hair and the inventors seem to know what they are talking about and sound very confident. http://www.freepatentsonline.com/20060147567.html Here are some extracts: -"The present invention relates to methods of increasing tyrosinase synthesis, expression, or activity in a cell comprising administering at least one grape seed extract to the cell." -"In another embodiment, the invention provides a method that includes topically applying a composition of GSE and a cosmetically suitable vehicle to the scalp of a mammal or other location where gray hair is present, to increase tyrosinase gene expression or melanin synthesis and thereby decrease gray appearance." I bought some Grape Seed Extract the other day so I am going to try this immediately (daily) and see if anything happens in about 3 months. I will keep using the topical Lac-Hydrin Retin-A 3 times a week.
I wonder if the "tyrosinase synthesis" has the same potential risks as tyrosine supplements relative to development of melanomas? I guess since it's topical that risk would be isolated to the scalp areas it is applied to. Interesting, please keep us posted! | | Back to Top | | |
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Alessio
Registered Member
Date Joined May 2007
Total Posts : 104
| Posted 10/15/2007 11:56 AM (GMT -5) | | | | |
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reverse
Registered Member
Date Joined May 2006
Total Posts : 64
| Posted 10/15/2007 12:09 PM (GMT -5) | | | I thought liposomes were able to penetrate the scalp? | | Back to Top | | |
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Alessio
Registered Member
Date Joined May 2007
Total Posts : 104
| Posted 10/17/2007 9:45 AM (GMT -5) | |
zorba990 said...
I would guess that the proper amount mixed with DMSO would be as effective as injection. LEF sells a DMSO gel.
The common side effects I've read from the Melanotan board include nausea and hyperpigmentation. I believe that hyperpigmentation is more prevelant with MTII than MTI but I'd just go join the MT board if you are interested in finding out more.
I still think the stimulation of melanocytes is at best a temporary fix. Stimulating more stem cell production to replace the damaged/dying/dead melanocytes along with large amounts of oral and topical antioxidants to extend the lifespan of the current melanocytes seems key.
Zorba990 you seem to have a lot of knowledge about stem cell treatments. What do you think when such treatments could be commercially available, because correct me if I am wrong this research is still in the lab and they don`t have immediate plans to take it in the clinic. And do you think that white hair (without melanocytes) could still reverse back to its original colour? Thanks! | | Back to Top | | |
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zorba990
Registered Member
Date Joined Jul 2004
Total Posts : 710
| Posted 10/17/2007 6:03 PM (GMT -5) | |
Alessio said...
zorba990 said...
I would guess that the proper amount mixed with DMSO would be as effective as injection. LEF sells a DMSO gel.
The common side effects I've read from the Melanotan board include nausea and hyperpigmentation. I believe that hyperpigmentation is more prevelant with MTII than MTI but I'd just go join the MT board if you are interested in finding out more.
I still think the stimulation of melanocytes is at best a temporary fix. Stimulating more stem cell production to replace the damaged/dying/dead melanocytes along with large amounts of oral and topical antioxidants to extend the lifespan of the current melanocytes seems key.
Zorba990 you seem to have a lot of knowledge about stem cell treatments. What do you think when such treatments could be commercially available, because correct me if I am wrong this research is still in the lab and they don`t have immediate plans to take it in the clinic. And do you think that white hair (without melanocytes) could still reverse back to its original colour? Thanks!
There are several supplements (mostly what LEF reccomends) which will boost your own production. I believe there is a list earlier in this thread.
and other general antiaging seems possible but they would probably need a solid business case to proceed with trials.
Post Edited (zorba990) : 10/17/2007 9:53:59 PM (GMT-4) | | Back to Top | | |
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TP
Registered Member
Date Joined Oct 2007
Total Posts : 6
| Posted 10/22/2007 10:30 AM (GMT -5) | | | I appologize for interupting, but was reading a post by lei.talk about creatine supplement protocol; and zorba999 seemed knowledgable in that conversation. I wondered if you could direct me to sources for valine, taurine and dextrose. | | Back to Top | | |
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Alessio
Registered Member
Date Joined May 2007
Total Posts : 104
| Posted 10/29/2007 9:31 AM (GMT -5) | | | | |
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dLaertios
Registered Member
Date Joined Apr 2006
Total Posts : 119
| Posted 11/4/2007 9:14 PM (GMT -5) | | | http://www.antiaging-wellness.com/Pages/Treatments/Hair/grey_hair.php
I remember someone saying that he would use topical application of clove oil. What happened?
I'll try to use clove oil for topical. The strong smell is an issue that prevented me from further use but
Eugenol Oil - the principal active ingredient in cloves and clove oil, applied topically to the scalp has been demonstrated to restore hair color.
it seems that worth trying.
Retin-A combined with AHA
Has anyone managed to make topical following this remedy? | | Back to Top | | |
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