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zorba990
Registered Member
     
Date Joined Jul 2004
Total Posts : 710
| Posted 12/5/2007 11:34 AM (GMT -5) |   | |
I'm not understanding this quote in the article:
"Suppressing NF-kappa-B on a long-term basis could result in cancers or other diseases, said the researchers, whose findings are reported today in the journal Genes and Development"
Since blocking NF-kappa-B slows cell division wouldn't the trade off be about equal?
(e.g. slow apoptosis but also slower cell division)
Cat's Claw herbal inhibits nuclear factor kappa B:
An extract of Uncaria tomentosa inhibiting cell division and NF-kappa B activity without inducing cell death.
Int Immunopharmacol. 2003 Dec;3(13-14):1889-900.
Previous reports have demonstrated that extracts of the plant Uncaria tomentosa inhibit tumor cell proliferation and inflammatory responses. We have confirmed that cat's claw C-Med 100, a hot water extract of this plant, inhibits tumor cell proliferation albeit with variable efficiency. We extend these findings by showing that this extract also inhibits proliferation of normal mouse T and B lymphocytes and that the inhibition is not caused by toxicity or by induction of apoptosis. Further, the extract did not interfere with IL-2 production nor IL-2 receptor signaling. Since there was no discrete cell cycle block in cat's claw C-Med 100-treated cells, we propose that retarded cell cycle progression caused the inhibition of proliferation. Collectively, these data suggested interference with a common pathway controlling cell growth and cell cycle progression. Indeed, we provide direct evidence that cat's claw C-Med 100 inhibits nuclear factor kappa B (NF-kappa B) activity and propose that this at least partially causes the inhibition of proliferation.
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zorba990
Registered Member
Date Joined Jul 2004
Total Posts : 710
| Posted 12/7/2007 11:20 AM (GMT -5) | | Update:
Negative results with Fenugreek CO2 extract. Lost a bit of hair on this one so taking one for the team sometimes <g>. Still holding on at perhaps 5% gray (just a bit in the front).
(Hoping my initial observations on Hyaluronic acid/Ultrasound facial treatment re-stimulating the hairline are correct). Trying adding thymus polypeptides next, since they activate stem cells. Using Enzymatic Therapy's product, but looking for something better (something specifically standardized as to the fractions would be good). http://www.fasebj.org/cgi/reprint/03-0244fjev1.pdf
Looks like getting an injectable quality thymus extract
might be the way to go. That way there are no fillers
that are annoying in preparing topicals. Looks rather
expensive, at 1 ampule per week that's still $13.00 a week
which would certainly make it the most expensive ingredient
in the topical.
Looking for anything cheaper/better in the way of liquid
thymus extracts...
Post Edited (zorba990) : 12/7/2007 9:38:06 PM (GMT-5) | | Back to Top | | |
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ttc
Registered Member
Date Joined Dec 2007
Total Posts : 2
| Posted 12/8/2007 10:19 PM (GMT -5) | | I just wanted to add that I am a 45 year old female and started going gray at 40. My mother has hardly any gray hair at 79
and my father (now deceased) was prematurely gray at 19. I could go both ways but have been working hard the past five years
to keep the gray at bay and reverse it, if possible.
I have studied and learned that the cells in the hair follicle will stay alive if they are fed properly (oxygen, minerals, enzymes and vitamins). When they are not getting what they need, they die off. My gray hair has gone away considerably this past year. I started exercising up to 60 minutes or more per day, ate more green (chlorophyll) foods, drank more water, got off white sugar/white flour products and went to bed earlier. I can't say which factor is the determining factor, because they all work together. I have noticed that the hair reversal happened over a matter of weeks. I eat raw wheat sprouts and take wheat grass juice along with other vegetables. I wish I could say I have been scientific about this, but I haven't. To sum it up, eliminating junk food, eating chlorophyll and exercising have made the most difference.
I also say that those who claim that "one" of these factors didn't work, haven't put the whole picture together. Just because you took chlorophyll but didn't exercise or stay off junk food, doesn't mean the chlorophyll didn't work in reversing the gray. All these factors are important for various reason. When someone says they are "watching" what they eat, they may still be on a relatively processed food diet high in cooked foods and low in high water content food. It would take someone disciplined to put all the factors into practice to truly see if their grey hair could be reversed. | | Back to Top | | |
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dLaertios
Registered Member
Date Joined Apr 2006
Total Posts : 119
| Posted 12/11/2007 4:53 PM (GMT -5) | | | Gotsomegrey,
you are in a good remedy.
I found a book of a greek Dr and said that greying of hair comes from B3 and copper deficiency. This deficiency makes the pores larger and then air bubbles formed and won't let melanin sit on hair shaft.
That's my theory also.
Furthermore said that correcting the deficiency won't reverse the grey hair but will protect new hair from becoming grey as well.
Tell us what will happen with your remedy, but as far as I've read maybe u need to up your C intake to 5-7 grams per day. | | Back to Top | | |
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vlc
Registered Member
Date Joined Dec 2007
Total Posts : 8
| Posted 12/26/2007 4:32 PM (GMT -5) | | | How common is it for a few grey hairs to revert back to normal colour and structure (the first few cm of the tip is grey but the rest down to the root is normal colour and shape)? | | Back to Top | | |
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magha
Registered Member
Date Joined May 2006
Total Posts : 40
| Posted 12/28/2007 9:59 PM (GMT -5) | | | Exercise /Diet.
I've noticed when I go off my normal diet (wintertime I eat alot more and get as lazy as the next guy in the cold weather) I do see alot of cholesterol deposits released through the skin (including top of head) especially when the skin is drier in the winter. If I exercise reg. and eat well, the skin is free of this, but I must do both or the condition returns.. I read much of this is from excess cholesterol (and cholesterol forming foods which are most starches and sugars). By the way, fructose is also found to be a potent cholesterol forming agent in studies.
The skin's pore mechanisms have to be affected to rid of this excess waste. It is the skins fuction to do this, but obviously the pore's function gets more "constipated" the more waste there is that needs to be eliminated through the skin. This does not optimize cellular function, even if it is directed via genetic codings.
Aerobic workout (cardio/Vo2) is still the most potent mechanism for optimizing cellular function of the entire body including the very crucial -- lymphatic system. The critical factor here is progression-- which is not found by forcing ourselves to do the minimum because we want to get it over, but by forcing our body towards increased progress every week. A rule to remember here is: Do what you have always done and you will get what you have always gotten.
There's not a significant amount that can be done to alter gentic codings, but there is a significant amount that can be done to optimize our cellular mechanisms so that premature loss in cellular function does not occur--and not only in the parts (hair, skin , etc.) but more importantly of the whole.
If the whole is conditioned, its more likely that the parts will follow-- it rarely (if ever) will occur in reverse. | | Back to Top | | |
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Jim Green
Registered Member
 
Date Joined Oct 2007
Total Posts : 16
| Posted 1/11/2008 2:45 PM (GMT -5) | | Greying hair [Wikipedia/hair color, Wikipedia/Grey Hair] is sometimes described as due to stem cell failure that no longer renews a melanocyte hair coloring cell in the hair follicle, so that the melanocyte dies and the hair turns white. This was a news story in 2004. I am not sure yet whether stem cell renewal via telomerase activation can restore the melanocyte to the hair follicle after the transition has taken place. I note that Geron and Telomolecular Nanotechnologies seem to believe that white hair can be restored to normal dark hair using telomerase activation. There are products on the market now that claim to restore hair and hair color with telomerase activation, such as iGrowHair Telomerase I sometimes imagine that my hair is getting darker as I experiment with telomerase activation, but then my hair looks dark after a shower when it is wet, and greyer later...perhaps explaining ancient popular belief in baptism. Just plunking a handful of water on the top of my head makes me look 5-10 years younger - it must help!
For telomerase activation I take Gaia astragalus extract at 5 mg of astragalosides per day for half of the month. This is an ethanolic extract taken orally at 30 drops per mg of astragalosides, which costs about $22 per month. I have also tried rubbing an entire bottle of Gaia astragalus extract in glycerin through my hair all over myself. However, you have to add about 20 population doublings to your telomeres before hair rejuvenation effects are observed, according to Artandi Labs and other telomere/telomerase research outfits, and I figure it may take a couple of years for me to remodel my telomeres with this cyclic telomerase activation scheme, in which I take no telomerase inhibitors such as resveratrol, quercetin, green tea, alpha tocopherol, fish oil, or garlic while using telomerase activators such as astragaloside iv. | | Back to Top | | |
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zorba990
Registered Member
Date Joined Jul 2004
Total Posts : 710
| Posted 1/12/2008 6:00 PM (GMT -5) | |
Jim Green said...
Greying hair [Wikipedia/hair color, Wikipedia/Grey Hair] is sometimes described as due to stem cell failure that no longer renews a melanocyte hair coloring cell in the hair follicle, so that the melanocyte dies and the hair turns white. This was a news story in 2004. I am not sure yet whether stem cell renewal via telomerase activation can restore the melanocyte to the hair follicle after the transition has taken place. I note that Geron and Telomolecular Nanotechnologies seem to believe that white hair can be restored to normal dark hair using telomerase activation. There are products on the market now that claim to restore hair and hair color with telomerase activation, such as iGrowHair Telomerase I sometimes imagine that my hair is getting darker as I experiment with telomerase activation, but then my hair looks dark after a shower when it is wet, and greyer later...perhaps explaining ancient popular belief in baptism. Just plunking a handful of water on the top of my head makes me look 5-10 years younger - it must help!
For telomerase activation I take Gaia astragalus extract at 5 mg of astragalosides per day for half of the month. This is an ethanolic extract taken orally at 30 drops per mg of astragalosides, which costs about $22 per month. I have also tried rubbing an entire bottle of Gaia astragalus extract in glycerin through my hair all over myself. However, you have to add about 20 population doublings to your telomeres before hair rejuvenation effects are observed, according to Artandi Labs and other telomere/telomerase research outfits, and I figure it may take a couple of years for me to remodel my telomeres with this cyclic telomerase activation scheme, in which I take no telomerase inhibitors such as resveratrol, quercetin, green tea, alpha tocopherol, fish oil, or garlic while using telomerase activators such as astragaloside iv.
Interesting post. Given the short half life of many of these substances, why not just take the telomerase activators before sleep when the body goes into its repair mode, and take the antioxidants during the day (prior to exercise, sun exposure, stress, etc)?
Astragalus is usually paired with Ginseng in Chinese medicine, and astragalus, ginseng, and Fo-Ti (contains resveratrol) all have high reputations for anti-aging rejuevenation effects. (There are many ginsengs so plant identification may be an issue here)
Re:
Wow. Expensive.
"live and active, telomerase excreting Acidophilus and other Live and active probiotic Yogurt cultures"
Huh? What bacteria culture produces Telomerase?
Not at all impressed with his hairline on the MySpace page...
However, he may be unaware of the possible need for wounding with
rejuvenation therapies.
What might miake sense is that a normal scalp might contain friendly
yeasts, while an abnormal scalp (for whatever reason chicken/egg)
might contain more pathogenic yeast (thus dandruff, increased oxidation
and sebum, etc).
To be legal it would have to be a strain that is already allowed to be sold,
like
Post Edited (zorba990) : 1/13/2008 5:00:35 PM (GMT-5) | | Back to Top | | |
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Redneck Rivera
Registered Member
Date Joined Jun 2005
Total Posts : 64
| Posted 1/21/2008 11:20 AM (GMT -5) | | | | |
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Vincentvangogo
Registered Member
Date Joined May 2006
Total Posts : 30
| Posted 1/23/2008 12:54 PM (GMT -5) | | | I was curious about that 636 stuff, Rivera interested to know how you get on. I've been trying the yogic rubbing fingernails/ acupressure technique for 2-3 months, but no obvious result so far. | | Back to Top | | |
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dejan
Registered Member
Date Joined Jan 2008
Total Posts : 2
| Posted 1/28/2008 10:16 AM (GMT -5) | | | dLaertios, do you have another improvement in reversal?? I'm very interested. | | Back to Top | | |
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Vincentvangogo
Registered Member
Date Joined May 2006
Total Posts : 30
| Posted 2/4/2008 6:59 PM (GMT -5) | | | DLaertios do you know if its as good to use ionic copper rather than colloidal? From what I've read some people think ionic is better absorbed. | | Back to Top | | |
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Russell22
Registered Member
Date Joined May 2007
Total Posts : 10
| Posted 2/7/2008 2:12 PM (GMT -5) | | | I have been attempting to reverse my grey hair for the last 7-8 months or so. I have varied the dosages and things i have taken, so have not had a stable supplement but have tried all the things, or most of them anyway, that have been suggested.
I was using topically reminex grey hair shampoo since july 07.
I'm taking orally
1 mega multivitamin
1 x vit c 1 gram
3-5 brewer's yeasts per day
1 x cod liver oil/omega 3 1 gram
over the last couple of months i have added the following
1 x L-tyrosine 500 mg
1 x blackstrap molasses 75 mg
1 x paba 500 mg
I can't say i have seen, using the above ingredients, any difference to my hair..i think reminexs shampoo is a complete waste of time and am just using up what i have left.
if anyone can think of anything else i should be taking please let me know. Also i bought a bottle of ionic copper i think..couldn't find colloidal anywhere. I started to use this topically too but kept forgetting to do this. Might try this again though.
Personally a bottle of hair dye is prob what is easiest and cheapest. What we must remeber is that grey hair is a natural bodily process that all humans and some animals go through..it isn't some diesease that we have here folks! There prob isn't a defined cure at this moment in time. Some things seem to work for some but not others. Personally nothing so far has worked for me. I have read that some people here are taking very high levels of vit c and other vitamins. I have been told by a doctor this is very very bad for you to be taking such high dosages every day, so this has made me cautious.
Also can anyone recommend a good hair dye? i have taken just for men but it just doesn't bond to my hair properly. I have quite thick hair and i only get about 50% coverage from it. Sometimes i have to re-apply 3 times just to get a reaonable coverage!! Has anyone else found this? i have brown hair (with grey in it) but i also get a slight red tint to it as well..its not noticable in normal light conditions but under harsh artificial light you can really see it which has made me a bit paranoid!! has anyone else found this?
Post Edited By Moderator (DDye) : 2/7/2008 1:16:01 PM (GMT-5) | | Back to Top | | |
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AussieDavid
Registered Member
Date Joined Mar 2006
Total Posts : 181
| Posted 2/10/2008 8:55 PM (GMT -5) | |
rik30 said...
I'm wondering if the use of finasteride has gotten my grey hair worse, my greying propably started some time after I began using fin but maybe this is just a coincidence as grey runs in my family though I read somewhere that finasteride could cause premature greying.<!-- Edit --> I think that it is definitely possible that Finasteride causes premature greying. My greying is very far advanced for my age and I have been taking Finasteride for many years. I have two brothers around the same age and neither of them have any significant grey hairs. Neither of them has ever taken Finasteride. The unusual thing with my hair is that it really has gone straight to white, rather than going grey. I'm wondering if the Finasteride is causing increased wnt protein production and those wnt proteins are inhibiting pigmentation, as they have been show to do in scientific research conducted by Follica. Follica has developed a potential new treatment for regrowing hair. Initially the new hairs were growing unpigmented, but when they inhibited wnt protein activity for the first 9 days of treatment, the hairs grew pigmented. In a post on hairlosstalk.com someone suggested being off Finasteride during the period when wnt activity is inhibited may help the hair to be pigmented. I don't understand any of the science here, just posting what I've read. I'm guessing that Finasteride increases wnt protein production. Healty hair follicles need wnt proteins. Somehow those same proteins can make the hair white, so it seems almost like a catch 22 situation.
Below is a paste from hairlosstalk.com directly talking about the new regrowth technique discovered by Follica. There is also a link below the paste directly to the hairlosstalk forum.
EXPRESSION OF WNT-I INHIBITORS DURING THE FIRST NINE PAYS
AFTER WOUNDING CAUSES PIGMENTATION OF NEW HF
MATERIALS AND EXPERIMENTAL METHODS
[000222] In this Example, doubly transgenic mice expressing both tetO-Dkkland K5-rtTA were utilized. When these mice are fed chow formulated with 1 g/kg doxycycline (BioServ, Laurel, MD), they express DkId , under the control of the K5 promoter, in the basaϊ epidermis. The control mice also received doxycycline, but they were K5-rtTA negative and thus did not express Dldd.
RESULTS
[000223] A 1 cm2 wound was induced on the lower back of the doubly transgenic mice at 21 days or 50 days old. Mice were placed on doxycycϊme-containing chow immediately after wounding to induce Dldd expression, and then doxycycline was discontinued after completion of the re- epithelialization at 9 days after wounding. Dkkl expression inhibits Wnt activity, which in turn induces follicle pigmentation. At 22 days after wounding, pigmented HF were observed in the excised skin after preparing the epidermal sheet (Figure 23 A-B). Control mice lacked pigmented HF (Figure 24).
[000224] In other experiments, continued expression of Dkkl after the 9-day period inhibited formation of new HF.
[000225] The findings of this Example show that pigmented HF can be produced by suppressing expression of Wntl or by inducing expression of Dkkl during the period of re-epithelialization, then inducing expression of Wntl . In addition, the findings of this Example show that factors that inhibit neonatal hair follicle formation (e.g. Dkkl ) also inhibit EDIHN, thus further supporting the notion mat hair follicles formed by EDIHN are similar to normal hair follicles.
Link to the forum:
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rick30
Registered Member
Date Joined Feb 2008
Total Posts : 18
| Posted 2/11/2008 12:45 PM (GMT -5) | | Thanks for the link AussieDavid, my hair is definitely going white fast so I'm going to stay off finasteride and see what happens.
Anyway I found a study online that showed that DHEA decreased the gray hairs on mice; also found a lot of posts on various forums that DHEA decreased the gray hair when taking DHEA orally.
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neuser123
Registered Member
Date Joined Feb 2008
Total Posts : 2
| Posted 2/19/2008 1:03 AM (GMT -5) | | | I've heard amazing things with BlackStrap molasses with reversal. | | Back to Top | | |
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rick30
Registered Member
Date Joined Feb 2008
Total Posts : 18
| Posted 2/19/2008 7:17 PM (GMT -5) | |
AussieDavid said...
rick30 said...
Anyway I found a study online that showed that DHEA decreased the gray hairs on mice; also found a lot of posts on various forums that DHEA decreased the gray hair when taking DHEA orally.
Be careful with DHEA. My doctor had me on it for about 18 months and I believe that it increased my hair loss. I was initially on a 50 mg Troche/day, but then cut back to 25 mg/day. I did sometimes feel like my heart was 'racing' a bit when I was taking it. I checked DHEA out and its actually not allowed to order without a prescription in my country so I guess I wont be adding it.
What about 7-keto, its supposed to have similar effects to DHEA
Also thinking about adding l-tyrosine, how much are you supposed to use daily?
Post Edited (rick30) : 2/19/2008 6:41:13 PM (GMT-5) | | Back to Top | | |
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