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The Life Extension Foundation Forums > LEF Public Forums > Dietary Supplements > Tribulus terrestris recent studies  Forum Quick Jump
 
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Tom.
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   Posted 1/20/2010 11:31 AM (GMT -4)    Quote This PostAlert An Admin About This Post.
Tribulus terrestris recent studies

Within 5 years of post date. Below are clickable links:

Antioxidant - Tribulus alatus, a relative of tribulus terrestis, Increases SOD, glutathione, ascorbic acid.

Erectile Dysfunction - Primates: Testosterone increase 52%, DHT 31%, DHEAS 29%.

Testosterone - A significant increase in the level of free serum testosterone, rat study.

Anti-cancer - Tribulus shown to be cytotoxic to cancer cells & less toxic on normal skin fibroblasts.

Anti-cancer - Tribulus saponins inhibited growth of renal carcinoma cells.

Heart - Cardiac fibroblast and myocyte protection from reduced oxygen and blood flow.

Hair - Tribulus extract increases hair follicle melanocytes.

Tribulus antibacterial and antifungal activities.

Post Edited (Tom) : 1/20/2010 11:23:26 PM (GMT-5)

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Tom.
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   Posted 1/20/2010 6:37 PM (GMT -4)    Quote This PostAlert An Admin About This Post.
Tribulus Terrestris — Depression, Well-being and Energy.

Monoamine Oxidase A (MAO-A) is a substance that can selectively metabolize adrenaline, noradrenaline, serotonin, and dopamine to inactive compounds. Tribulus contains the plant alkaloid called Harmine. This alkaloid is a short-acting, "reversible" Monoamine Oxidase A inhibitor (MAOI-A).

The inhibition of MAO-A prevents the degradation of adrenaline, noradrenaline, serotonin, and dopamine and the result can be increased mood, alleviation of depression and more energy. High dopamine levels can stimulate the pituitary gland to release lutenizing hormone (LH) which leads to an increase in testosterone levels and thus elevating libido, another mood enhancer.

Harmine is "reversible" because it does not bind permanently to MAO-A, thus is not as contraindicated with tyramine containing foods (cheese, red wine, etc) as irreversible MAOI's, nor does harmine raise levels of tyramine per se since it allows tyramine to be metabolized.

The short-acting and non-permanency of it's binding capabilities means that the anti-depressive effects of harmine usually cease 24-48 hours after stopping therapy. Tribulus has a very short half-life, about 2.5 hours, so divided doses throughout the day are necessary.

The discovered harmine in tribulus along with the hormonal modulating qualities supports the many anecdotal reports of tribulus increasing energy, libido and uplifting mood.

Therapy: 750 mg to 1,500 mg of pure, pharmaceutical grade tribululs "extract" standardized to at least 45% steroidal sapponins. Taken in divided doses 3 x per day. Positive effects and relief of symptoms usually occur within one week of continued daily use.

Tribulus - A potential source of harmine.

Acute harmine administration induces antidepressive-like effects.
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scottie99
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   Posted 2/3/2010 2:09 PM (GMT -4)    Quote This PostAlert An Admin About This Post.
Hi Tom. I like Trib, is there a brand you know of that's particularly good quality?
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Tom.
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   Posted 2/3/2010 8:26 PM (GMT -4)    Quote This PostAlert An Admin About This Post.
The one I like is Tribestan from Sopharma the Bulgarian pharmaceutical company, although it's a bit expensive.
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scottie99
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   Posted 2/4/2010 1:19 PM (GMT -4)    Quote This PostAlert An Admin About This Post.
Thank you, Tom.
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