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|  gpawelski Registered Member
       Date Joined May 2001 Total Posts : 114 | Posted 11/27/2005 11:11 PM (GMT -5) |   |
"Since a substantial number of patients presenting with lung cancer either smoked in the recent past or continue to do so, it is important to make sure that the patient stops smoking as soon as possible to improve their treatment outcome," says Dr. Carolyn M. Dresler, Head, Tobacco and Cancer Group of the International Agency for Research on Cancer. She added, "the emphasis should be on improvement of treatment outcome and future health improvement."
There are guidelines regarding smoking cessation techniques that have resulted from reviews of the world's literature and are very well accepted throughout the medical and psychological fields. However, "the biggest problem remains in having healthcare providers implement them routinely," Dr. Dresler says, "Most have emphasized the role of the primary healthcare provider in providing smoking cessaton advice to patients, whereas the specialists, such as medical oncologists, radiation oncologists, thoracic surgeons or pulmonary care specialists should be dealing with the health problems resulting from the smoking as the patient faces imminent interventions such as radiation therapy, chemotherapy or surgery."
She makes the point that since ongoing smoking may significantly affect the outcome of subsequent surgery or therapy and negatively impact long-term survival, it is now the specialists' turn to provide the urgent smoking cessation treatment. With the advent of medicare changes under the new Medicare Modernization Act (MMA), the specialists will be reimbursed for providing evaluation and management services, making referrels for diagnostic testing, radiation therapy, surgery and other procedures as necessary, and offer any other support needed to reduce patient morbidity and extend patient survival. I certainly hope they add smoking cessation guidance and support.
www.treatobacco.net is an evidence-based site containing information in 11 languages on tobacco dependence treatment relative to efficacy, safety, demographics and health effects, health economics, and policy.
www.cdc.gov/tobacco/ is a site to let you know everything you wanted to know about tobacco at the CDC.
www.guideline.gov/summary/summary.aspx?doc_id=2958&nbr=2184 is the National Guideline Clearinghouse web site for smoking cessaton. Gregory D. Pawelski | | Back to Top | | |
  |  gpawelski Registered Member
       Date Joined May 2001 Total Posts : 114 | Posted 12/1/2005 2:21 PM (GMT -5) |   | |
Smoking, The Missing Drug Interaction in Clinical Trials: Ignoring the Obvious
Ellen R. Gritz,1 Carolyn Dresler,2 and Linda Sarna3 Department of Behavioral Science, The University of Texas M.D. Anderson Cancer Center, Houston, Texas; 2Tobacco and Cancer Group, IARC, Lyon, France; and 3School of Nursing, University of California-Los Angeles, Los Angeles, California
Abstract
Tobacco use is universally recognized as the foremost preventable cause of cancer in the United States and globally and is responsible for 30% of all cancer-related deaths in the United States . . . We explain the critical value of knowing the smoking status of every patient with cancer at every visit by providing a brief overview of the following research findings: (a) the effects of tobacco use on cancer treatment and outcome; (b) recent findings on the role of nicotine in malignant processes; (c) some unexpected results concerning tobacco status, treatment, and disease outcome; and (d) identifying key questions that remain to be addressed. We provide a suggested set of items for inclusion in clinical trial data sets that also are useful in clinical practice
(Cancer Epidemiol Biomarkers Prev 2005;14(10):2287–93)
Conclusions
We can no longer ignore the obvious: smoking is a critical variable that affects cancer treatment and outcome and has been shown to vitiate or interact with the effects of some therapeutic agents and chemopreventive agents. Measurement of smoking history and status in clinical trials of cancer therapy will increase our knowledge of the adverse effects of the constituents of tobacco smoke, including nicotine, and of drug interactions.
Oncology health professionals have called for increased advocacy for tobacco control. Furthermore, the routine inclusion of smoking status and cessation need to become a standard of care for all patients. The inclusion of smoking data in oncology clinical trials will also provide clinicians with improved means of delivering individualized advice to patients with cancer that may be critical in motivating their cessation efforts and sustained abstinence.
Scientific, financial, and clinical support is critical to this goal. The failure to date to assess, analyze, and report smoking status has limited our ability to investigate the effect of smoking on treatment efficacy and outcome. The time has come to integrate data about the single most important lifestyle risk factor in cancer prevention into cancer treatment and survivorship trials.
No "pharmaceutical" trial ever followed whether patients smoked during their clinical trials, despite dosing themselves daily with cigarettes with 4000 chemicals in them. The addition of nicotine inhibits the ability of a chemo drug (like etoposide) to induce apoptosis by 61%. If a drug like nicotine, which occurs in the highest concentration of any drug in a cigarette, inhibits the ability of a major chemotherapy drug by 61%, a medical oncologist should care if it was being ingested during treatment.
The vast majority of clinical trails performed are ones that test one chemotherapeutic regimen against another. Single arm clinical trials provide the tumor response evidence that is the basis for approving new cancer drugs. The randomized, controlled clinical trial may likely remain the standard for evidence of clinical decision-making in cancer medicine, however, observational methods and systematic reviews are clearly useful. Even with the importance of clinical trials, it is crucial to work on reducing their inherent limitations, including uncertain generalizations, and to expand the use of the randomized clinical trial paradigm to areas beyond proving biological activity, like diagnostic testing.
Evidence based medicine, since the 1970's, depended upon the randomized, controlled trial. It rests upon the assumption that evidence should be determined and applied as a basis for medical decision-making. Evidence is based upon quantities, similarities, populations, and averages, rather than qualities, idiosyncracies, individualization, and specifics. It would be surprising if the most ardent supporter of evidence based medicine would ever advocate a randomized trial for an intervention in which an observational study showed remarkable efficacy in preventing a near death situation. Many major medical advances have never been subjected to a prospective randomized study before being introduced into routine management because their beneficial effects have been obvious.
Recognizing the reliability of the evidence upon which clinical practice has increasingly come to depend, the time has come for physicians to reassess the value of direct observation, and to trust more readily both the empirical and intuitive discoveries they make each day in their personal experience, even if those discoveries are contradicted by the best available evidence. There could be nothing more serious than the call for physicians to reconsider what it means to be authentic and true.
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   |  Mother Margaret Registered Member
       Date Joined Jan 2005 Total Posts : 323 | Posted 12/29/2006 2:26 PM (GMT -5) |   | |
The soft tissue sarcomas are most probably the result of a chemical poisoning through the decades ... that shows up especially in all war periods since the 14th century. So, we should be looking for what is alike for our WW II vets, our Vietnam vets, our Korean Vets, our "Gulf war Syndrome" vets and today's soldier, and our civilians with CFIDS, CFS, FM.
Too bad mesothelioma lung cancer is tagged to asbestos and innocent companies are being robbed by high class attorneys who have found a deep pocket ... and who cares what the real truth is ... Ford Motor Company being sued for asbestos in break linings. What do they think break fluid is?
Info on 2-butoxyethanol
This is the list of harm put forward by the Vietnam vets. Except for the couple of things dioxin (Agent Orange does) ... the rest of the list of what happened to the Vietam vet is the same for WWII vets and others:
Actually I already excluded the item that Dioxin would cause ...
PSA - Avoid 2-BE - Hypothalamus? Soft tissue sarcomas ... all of themNon-Hodgkin's lymphoma Hodgkin's disease Porphyria cutanea tarda Respiratory cancers (lung, larynx, trachea) Prostate cancer Multiple myeloma Hepatobiliary cancers Nasal/nasopharyngeal cancer Bone cancer Female reproductive cancers (breast, cervical, uterine, ovarian) Renal cancer Testicular cancer Leukemia Spontaneous abortion Birth defects Neonatal/infant death and stillbirths Low birthweight Childhood cancer in offspring Abnormal sperm parameters and infertility Zero Sperm Cognitive and neuropsychiatric disorders Memory LossMotor/coordination dysfunction Peripheral nervous system disorders Skeptical? @ ALSMetabolic and digestive disorders (diabetes, changes in liver enzymes, lipid abnormalities, ulcers) Immune system disorders (immune modulation and autoimmunity) Circulatory disorders Respiratory disorders Skin cancer Gastrointestinal tumors ( stomach cancer, pancreatic cancer, colon cancer, rectal cancer) Bladder cancer Brain tumors The Chemical exposure that would do ALL of these things was the other chemical in the mix:
Ethylene glycol monobutyl ether or modern name since its widespread use 1930s on is 2-butoxyethanol. It causes autoimmune hemolytic anemia that is hard to find ... but findable.
It causes lots and lots of birth defects & people are easily exposed today.
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