There are no studies on humans, but they have done studies on mice (who share 80% of our genetic make-up) and using mathematics the doctors claim the amount they gave the mice would be equivalent to 155 mg on a 2,000 daily calorie diet (from Dr. David Sinclair's laboratory at Harvard whose results were published in the journal Nature).

I think doctors should study this supplement on Chimpanzee's instead of mice. Chimps share over 98% of our genetic make-up so I assume more accurate and precise results could be generalized to humans if those animals were studied.

Post Edited (albedo) : 6/10/2008 6:48:41 AM (GMT-4)

I've been reading everything I can find in the medical journals about resveratrol, including chasing down the references of any article on it published here at LEF.

I thought they must have figured out how to keep resveratrol active given that there are now so many resveratrol supplements on the market.  But, the medical literature is still consistent that activity of trans-resveratrol peaks at around 60 minutes because it is rapidly conjugated to a sulfate metabolite, and there is absolutely zero evidence that the metabolites have any positive benefit. So dosing doesn't matter at all if it's rapidly converted into something that has no benefit.

If someone can direct me to any research which justifies the use of a resveratrol supplement by showing it remains active for any reasonable length of time, I would very much appreciate it. And I would also direct caution about reading the claims of supplement manufacturers, including LEF.  In some of the literature reviews offered here as a way of supporting the use of their resveratrol supplements, authors will state that it was the resvertatrol that caused the effect seen in the medical study, when if you read the study itself, resveratrol was used in combination with other grape/berry antioxidant mixes, and the research authors of the medical studies indicate that it is their conclusion that the total antioxidant pool was the factor causing the outcome, not  necessarily the resveratrol. the Linus Pauling Foundation concludes the same, and they are unable to conclude that supplemental resveratrol has any efficacy.

I'd love to find a resveratrol supplement that really works, but I don't think there is one.  I think this is the reason it's taking Sirtuis [the maker of the pharma version] so long to formulate; the activity of the molecule is difficult.