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Hormoneman
Respected Member

Date Joined May 2006
Total Posts : 2578

Posted 8/27/2009 11:39 AM (GMT -5)

http://physiolgenomics.physiology.org/cgi/content/full/23/3/343

"To facilitate the development of assays for the discovery of pharmaceuticals capable of mimicking the effects of caloric restriction (CR) on life- and healthspan (CR mimetics), we evaluated the effectiveness of glucoregulatory and putative cancer chemopreventatives in reproducing the hepatic gene expression profile produced by long-term CR (LTCR), using Affymetrix microarrays . . . Eight weeks of metformin treatment was superior to CR8 at reproducing LTCR-like gene expression changes, maintaining a superior number of such changes over a broad range of statistical stringencies, and producing more Gene Ontology terms overlapping those produced by LTCR. Consistent with these results, metformin has been shown to reduce cancer incidence in mice and humans.

Consistent with the evidence presented here, chronic MET treatment of female transgenic HER-2/neu mice increased their mean lifespan by 8% and their maximum lifespan by 13% (3). . .

SpainEurope
Registered Member

Date Joined Dec 2008
Total Posts : 464

Posted 8/31/2009 1:08 PM (GMT -5)

Metformin has many side effects at long term use.

Hormoneman
Respected Member

Date Joined May 2006
Total Posts : 2578

Posted 9/1/2009 1:49 PM (GMT -5)

And they are??

SpainEurope said...
Metformin has many side effects at long term use.

"Maybe this world is another planet's Hell."

Aldous Huxley

SpainEurope
Registered Member

Date Joined Dec 2008
Total Posts : 464

Posted 9/1/2009 3:20 PM (GMT -5)

Metformin is possibly the best antidiabetes drug but over time it loses its effectiveness.

Not uncommon side effects: lactic acidosis, fatigue, muscle pain, slow heartbeat, cold skin.

"What your doctor may not tell you about diabetes" Dr Steven Joyal
"What the drug companies wont tell you and your doctor doesnt know" Dr Michael Murray

I think metformin is great drug but its better by far going on an antiinflamatory diet and taking supplements like omega-3, vitamin D, LEF Cinsulin...

Hormoneman
Respected Member

Date Joined May 2006
Total Posts : 2578

Posted 9/1/2009 3:38 PM (GMT -5)

Show the studies that prove your statements to be true.

SpainEurope said...
Metformin is possibly the best antidiabetes drug but over time it loses its effectiveness.

Not uncommon side effects: lactic acidosis, fatigue, muscle pain, slow heartbeat, cold skin.

"What your doctor may not tell you about diabetes" Dr Steven Joyal
"What the drug companies wont tell you and your doctor doesnt know" Dr Michael Murray

I think metformin is great drug but its better by far going on an antiinflamatory diet and taking supplements like omega-3, vitamin D, LEF Cinsulin...

SpainEurope
Registered Member

Date Joined Dec 2008
Total Posts : 464

Posted 9/1/2009 5:46 PM (GMT -5)

"Metformin-associated lactic acidosis: a prognostic and therapeutic study"
Critical Care Medicine, july 2009

"Systematic review: comparative effectiveness and safety of oral medications for type 2 diabetes mellitus"
Ann Intern Med. 2007 Sep

If you want more info, you can search, there are many researches and books published about metformin side effects at long term use.

Antiinflamatory diet is superior at long term use.

bullmastiff
Registered Member

Date Joined Apr 2007
Total Posts : 869

Posted 11/3/2009 6:19 PM (GMT -5)

Lowers testosterone - look on internet.

Hormoneman said...
And they are??

SpainEurope said...
Metformin has many side effects at long term use.

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