Post Edited (Cory75) : 8/23/2006 4:05:08 PM (GMT-4)

What do u guys think of the resveratrol pills sold outside of LEF (like VITACOST ones, for example)?

Are they equally as effective as the ones sold by LEF?

i WOULD APPRECIATE VERY MUCH IF SOMEONE ANSWERS THESE QUESTIONS. 

THANKS IN ADVANCE.

What dosage?

The human equivalent dose for a 160-pound adult would be about 1575 milligrams of resveratrol to produce the health benefits noted in the mouse study. The reporters didn’t read the study carefully, published in Nature Magazine, which said a lower-dose (~364 milligrams for a 160-pound adult) produced similar benefits.

Furthermore, the mice were engorged with fat, 60% of their daily calorie intake. Americans once consumed about 45% of daily calories from fat (1965), but that number has dropped to about 34% (2002). So a lower amount of resveratrol, maybe half as much (~180 mg) would likely be effective.

Dr. Richard Hodes, director of the National Institute on Aging, which helped support the study, also said that people should wait for the results of safety testing. Substances that are safe and beneficial in small doses, like vitamins, sometimes prove to be harmful when taken in high doses, Dr. Hodes said.

One person who is not following this prudent advice, however, is Dr. Sinclair, the chief author of the study. He has long been taking resveratrol, though at a dose of only five milligrams per kilogram. Mice given that amount in a second feeding trial have shown similar, but less pronounced, results as those on the 24-milligram-a-day dose, he said. 

Results of the Turquoise Killifish study

Using 157 turquoise killifish bred by an Italian drug development company, Lay Line Genomics (which funded the study and which holds the rights for commercial exploitation of this aging model), the researchers conducted experiments on the antiaging effects of resveratrol.3 Beginning when the fish reached sexual maturity at 4 weeks of age, the researchers gave them food (bloodworm larvae—yum!) that was supplemented with resveratrol at three different concentrations: 24, 120, and 600 micrograms of resveratrol per gram of food.* (A fourth group, the controls, received no resveratrol.) The fish were given defined amounts of food twice daily so that their resveratrol intake could be accurately known.

The results were astonishing: whereas all the control fish died by 12 weeks of age (as did the fish receiving the lowest dose of resveratrol), the fish receiving the two higher doses of resveratrol lived much longer. In the fish receiving 120 mcg/g of food, the median lifespan increased by 33%, and the maximum lifespan increased by 27%. In the fish receiving 600 mcg/g of food, the median and maximum lifespans increased by 56% and 59%, respectively.

Update: Looks like from this thread

http://www.imminst.org/forum/index.php?s=&act=ST&f=6&t=14124&st=0

that 98% Resveratrol might become available. 

Update2:

Here's a source:

http://www.resveratrolforhealth.com/page/specification_resveratrol_glycon.html

Post Edited (zorba990) : 3/17/2007 4:26:27 PM (GMT-4)

Post Edited (albedo) : 5/22/2008 4:05:43 PM (GMT-4)

There are no studies on humans, but they have done studies on mice (who share 80% of our genetic make-up) and using mathematics the doctors claim the amount they gave the mice would be equivalent to 155 mg on a 2,000 daily calorie diet (from Dr. David Sinclair's laboratory at Harvard whose results were published in the journal Nature).

I think doctors should study this supplement on Chimpanzee's instead of mice. Chimps share over 98% of our genetic make-up so I assume more accurate and precise results could be generalized to humans if those animals were studied.

Post Edited (albedo) : 6/10/2008 6:48:41 AM (GMT-4)

I've been reading everything I can find in the medical journals about resveratrol, including chasing down the references of any article on it published here at LEF.

I thought they must have figured out how to keep resveratrol active given that there are now so many resveratrol supplements on the market.  But, the medical literature is still consistent that activity of trans-resveratrol peaks at around 60 minutes because it is rapidly conjugated to a sulfate metabolite, and there is absolutely zero evidence that the metabolites have any positive benefit. So dosing doesn't matter at all if it's rapidly converted into something that has no benefit.

If someone can direct me to any research which justifies the use of a resveratrol supplement by showing it remains active for any reasonable length of time, I would very much appreciate it. And I would also direct caution about reading the claims of supplement manufacturers, including LEF.  In some of the literature reviews offered here as a way of supporting the use of their resveratrol supplements, authors will state that it was the resvertatrol that caused the effect seen in the medical study, when if you read the study itself, resveratrol was used in combination with other grape/berry antioxidant mixes, and the research authors of the medical studies indicate that it is their conclusion that the total antioxidant pool was the factor causing the outcome, not  necessarily the resveratrol. the Linus Pauling Foundation concludes the same, and they are unable to conclude that supplemental resveratrol has any efficacy.

I'd love to find a resveratrol supplement that really works, but I don't think there is one.  I think this is the reason it's taking Sirtuis [the maker of the pharma version] so long to formulate; the activity of the molecule is difficult.